A review on monkey pox

Monkey pox a vesiculo pustular rash illness was initially discover to cause human infection in 1970 through the world health organization (WHO) -sponsered efforts of commission certify small eradication In western Africa and congo basin . virus has been discovered non primate 1958 thus named monkey causative agents disease both are species orthopox virus,monkey when it effects as an epizootic produces similar clinical picture that ordinary smallpox since extensive epidemiology, virology,ecology, public research enable better characterization associated .we conducted sysmatic review peer-reviewed grey literacture on how epidimology evolved, with particular emphasis number confirmed, probable , possible cases,age at presentation geographical spread. The cases rise 1970s ,with most dramatic increases occurring DRC median age increased from 4 1970s) 21 years ( 2010-2019).There overall case fatality rate 8.7% significant difference between clades -central African 10.6% 95% CI: 8.4%-13.3% ) VS WestAfrican 3.6% CI:1.7%-6.8% .your shows escalation cases, especially highly endemic spread other countries, growing young children adults These findings may be related cessation vaccination which provided some cross -protection against monkeypox leading -to -human transmission. surveillance detection essential tools for understanding continousily changing epidemiology this resurging disease.